Inositol is POSSIBLY SAFE for most adults. It can cause nausea, tiredness, headache, and dizziness.
There are a few less common, but more serious, inositol side effects that you should report to your healthcare provider. These include but are not limited to:
Worsening of bipolar disorder (although this was reported in only one case and may have been caused by other factors)
Signs of an allergic reaction, such as:
Swelling of the mouth or throat.
Some preliminary results of studies on high-dose inositol supplements show promising results for people suffering from problems such as bulimia, panic disorder, obsessive-compulsive disorder, agoraphobia, and unipolar and bipolar depression.
In a single double-blind study on 13 patients, Myo-inositol (18 grams daily) has been found to reduce the symptoms of obsessive-compulsive disorder (OCD) significantly, with effectiveness equal to SSRIs and virtually without side-effects. In a double-blind, controlled trial, myo-inositol (18 grams daily) was superior to fluvoxamine for decreasing the number of panic attacks and other side-effects.
Patients suffering from clinical depression, in general, have decreased levels of inositol in their cerebrospinal fluid. A double-blind, placebo-controlled study of depressed patients showed that a high dose of inositol (12 grams daily) resulted in significant improvement of symptoms, with no changes noted in liver, kidney, or hematological function. A meta-analysis of randomized trials of inositol for depression was not able to determine if inositol is of benefit.